Microsphere high shear homogenization emulsifying tank

Nano microsphere, micron microsphere emulsification machine, batch emulsification machine, pipeline emulsification machine, emulsification machine to control the size of microsphere, ordinary emulsification machine, microsphere suspension polymerization, microsphere lotion polymerization, microsphere

Microemulsion polymerization

The main purpose of emulsification is to disperse the discontinuous phase into smaller droplets. The rotor stator device is particularly suitable for emulsification tasks. The combined effect of high shear force and high expansion force inside the mixing head makes the droplets smaller. In addition, large turbulence enables the rotor stator device to quickly transport emulsifier molecules onto the reformed surface.
Microspheres

Microsphere refers to a particle dispersion system formed by the dispersion or adsorption of drugs in polymers or polymer matrices. There are many carrier materials for preparing microspheres, mainly divided into natural polymer microspheres (such as starch microspheres, albumin microspheres, gelatin microspheres, chitosan, etc.) and synthetic polymer microspheres (such as polylactic acid microspheres)

Microsphere size: nanometer and micrometer

Nanospheres are generally polymerized by macromolecules, mostly resins, with lotion polymerization, polystyrene, polyacrylic acid...

The current definition of microspheres in pharmacy refers to tiny spherical entities, spherical or quasi spherical, formed by the dissolution or dispersion of drugs in polymer materials. They are generally prepared as suspensions for injection or oral use. The particle size range of microspheres is generally 1-500um, ranging from a few nanometers to up to 800um. Among them, those with a particle size less than 500nm are usually referred to as nanospheres or nanoparticles and belong to the colloidal category.

Ordinary and Craftsmanship

Option 1:
Raw materials: Oil phase, solid A: 10g, dichloromethane 50ml
Water phase, solid B: 20g, water 2kg
First, dissolve solid A and dichloromethane by stirring; Solid B and water are heated to 90 ℃, stirred and dissolved, and then cooled to 10-15 ℃ after sufficient dissolution. Ready to use.
Equipment configuration: 2P, 2G, 4M, three-stage emulsifier, dual inlet
Speed: 5000 revolutions per minute
Experimental steps: ⑴ First, add the aqueous phase into a vacuum tank, start stirring (scraping) in the vacuum tank at a speed of about 50 revolutions per minute, circulate cooling water, and cool down * * 10-15 ℃. ⑵ After the temperature drops by 10-15 ℃, start the emulsifier, add water phase, circulate, and slowly add oil phase from another inlet, about 3 minutes to complete 5000 revolutions per minute, cycle for 30 minutes Vacuumize for 2 hours Filter, dry
Option 2:
Raw materials: Oil phase, solid A: 10g, dichloromethane 50ml
Water phase, solid B: 5g, water 2kg
First, dissolve solid A and dichloromethane by stirring; Solid B and water are heated to 90 ℃, stirred and dissolved, and then cooled to 10-15 ℃ after sufficient dissolution. Ready to use.
Equipment configuration: 2P, 2G, 4M, three-stage emulsifier, dual inlet
turn
Difficulties to be solved: 1. Selection of the thickness of the stator and rotor, and how to handle it to the appropriate particle size (micrometers * optimal)
2. Method and time of adding oil phase
3. When vacuuming, the stirring speed

The three-stage high shear dispersion machine is mainly used for the production of micro lotion and ultra-fine suspension lotion. Since three groups of dispersion heads (stator+rotor) in the working chamber work at the same time, after high shearing, the lotion drops are more delicate and the particle size distribution is narrower, so the stability of the generated mixed liquid is better. The three sets of dispersing heads are easy to replace and suitable for different process applications. The different models of machines in this series have the same line speed and shear rate, making it very easy to scale up production. It also meets the CIP/SIP cleaning standards and is suitable for food and pharmaceutical production.

High rotational speed and shear rate are important for obtaining ultrafine suspension lotion. According to some industry specific requirements, its shear rate can exceed 15000rpm, and the rotor speed can reach 44m/s. Within this speed range, turbulence caused by shear forces combined with specially developed motors can reduce the particle size range to the nanometer level. The shear force is stronger, and the particle size distribution of lotion is narrower.

The following is a model table for reference:

Microsphere high shear homogenization emulsifying tank